AUTHOR=Ding Xiaohong , Yang Lili , Wang Jian , Tang Rong , Chen Qianqian , Pan Jiexue , Yang Haiyan , Chen Xia , Chen Zimiao , Mu Liangshan 

TITLE=Subclinical Hypothyroidism in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

JOURNAL=Frontiers in Endocrinology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2018.00700

DOI=10.3389/fendo.2018.00700

ISSN=1664-2392

ABSTRACT=<p><bold>Background:</bold> The association between subclinical hypothyroidism (SCH) and polycystic ovary syndrome (PCOS) has been reported in several studies, but it is not well-recognized. The aim of this study was to evaluate the prevalence of SCH in women with PCOS.</p><p><bold>Methods:</bold> An extensive literature search was conducted in PubMed, Embase, Web of Science, and Cochrane Library databases. All articles published before May 2018 was considered for eligibility. No language restrictions were implemented. The prevalence of SCH in PCOS was calculated by the meta-analysis to produce an odds ratio (OR) with 95% confidence interval (CI).</p><p><bold>Results:</bold> A total of 6 studies including 692 PCOS patients and 540 controls were eligible for the meta-analysis. The combined odds ratio (OR) of SCH risk for women with PCOS compared with controls was 2.87 (95% CI = 1.82–9.92; <italic>P</italic> &lt; 0.000001). The OR increased to 3.59 when limiting thyroid stimulating hormone (TSH) cut-off to ≥4 mIU/L.</p><p><bold>Conclusions:</bold> Women with PCOS are more likely to develop SCH.</p>