AUTHOR=Wu Di , Li Yinglu , Zhu Kathy S. , Wang Haiying , Zhu Wei-Guo 

TITLE=Advances in Cellular Characterization of the Sirtuin Isoform, SIRT7

JOURNAL=Frontiers in Endocrinology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2018.00652

DOI=10.3389/fendo.2018.00652

ISSN=1664-2392

ABSTRACT=<p>SIRT7 is one of seven mammalian sirtuins that functions as an NAD<sup>+</sup>-dependent histone/protein deacetylase. SIRT7 is the least well-known member of the sirtuin family, but recent efforts have identified its involvement in various cellular processes, such as ribosome biogenesis, gene expression, cellular metabolism and cancer. Here we provide an update on the functions and mechanisms of SIRT7 in cellular regulation and disease.</p>