AUTHOR=Hannon Tamara S. , Watson Sara E. , Jalou Hasnaa E. , Chakravorty Sangeeta , Mather Kieren J. , Arslanian Silva A. 

TITLE=Characteristics of Obstructive Sleep Apnea Across the Spectrum of Glucose Tolerance in Obese Adolescents

JOURNAL=Frontiers in Endocrinology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2018.00281

DOI=10.3389/fendo.2018.00281

ISSN=1664-2392

ABSTRACT=<sec id="ST1"><title>Background</title><p>It is not known if dysglycemia and sleep-disordered breathing are linked in adolescents, as in adults.</p></sec><sec id="ST2"><title>Objective</title><p>To perform a pilot study evaluating measures of sleep-disordered breathing across the spectrum of glucose tolerance in obese adolescents. We hypothesized that dysglycemia would be associated with sleep-disordered breathing.</p></sec><sec id="ST3"><title>Participants/methods</title><p>This was a prospective, cross-sectional clinical pilot study that included 57 adolescents [body mass index (BMI) 38.9 ± 8.4 kg/m<sup>2</sup>] aged 12–18 years (14.5 ± 1.6) with normal glucose tolerance (NGT), or dysglycemia [impaired glucose tolerance (IGT) or type 2 diabetes (T2D)].</p></sec><sec id="ST4"><title>Measures</title><p>Anthropometrics, overnight polysomnogram, and oral glucose tolerance tests were performed. Participant characteristics and outcome measures were compared by glucose tolerance status. Correlational analyses were conducted to assess the associations between variables of interest.</p></sec><sec id="ST5"><title>Results</title><p>Participants with dysglycemia (<italic>n</italic> = 21) were not different from those with NGT (<italic>n</italic> = 36) for BMI, waist circumference, body fat, or sleep characteristics. Nocturnal oxygen desaturation was associated with higher BMI (<italic>r</italic> = −0.334, <italic>p</italic> = 0.012). The apnea–hypopnea index (AHI) was not associated with physical and metabolic parameters. Although participants with dysglycemia tended to have higher AHIs (median 3.2, 2.2, and 1.6 events/h for T2D, IGT, and NGT, respectively), there was not a linear relationship between measures of glycemia and AHI.</p></sec><sec id="ST6"><title>Conclusion</title><p>Further study with a larger proportion of youth with prediabetes and T2D is necessary to determine whether evaluation for sleep-disordered breathing is uniformly warranted.</p></sec>