AUTHOR=Li Yan-Yan , Lu Xin-Zheng , Wang Hui , Yang Xin-Xing , Geng Hong-Yu , Gong Ge , Zhan Yi-Yang , Kim Hyun Jun , Yang Zhi-Jian TITLE=Solute Carrier Family 30 Member 8 Gene 807C/T Polymorphism and Type 2 Diabetes Mellitus in the Chinese Population: A Meta-Analysis Including 6,942 Subjects JOURNAL=Frontiers in Endocrinology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2018.00263 DOI=10.3389/fendo.2018.00263 ISSN=1664-2392 ABSTRACT=Background

Although solute carrier family 30 (zinc transporter) member 8 (SLC30A8) gene 807C/T polymorphism is associated with an increased risk of type 2 diabetes mellitus (T2DM) risk, there remains some inconsistency between individual studies.

Objective

The aim of the study is to explore the relationship between SLC30A8 gene 807C/T polymorphism and T2DM in the Chinese population.

Methods

The current meta-analysis compiles and analyzes the data of 6,942 participants from 10 independent studies. Either a fixed or random-effects model was adopted to evaluate the pooled odds ratio (ORs) and the corresponding 95% confidence interval (95% CI).

Results

A significant association between SLC30A8 gene 807C/T polymorphism and T2DM was found in the Chinese population under allelic (OR: 0.85, 95% CI: 0.80–0.91, P = 7.42 × 10−7), recessive (OR: 0.52, 95% CI: 0.38–0.72, P = 8.49 × 10−5), dominant (OR: 2.40, 95% CI: 1.68–3.41, P = 1.30 × 10−6), homozygous (OR: 0.52, 95% CI: 0.40–0.67, P = 2.90 × 10−7), heterozygous (OR: 0.79, 95% CI: 0.71–0.88, P = 1.63 × 10−5), and additive genetic models (OR: 0.73, 95% CI: 0.64–0.83, P = 7.05 × 10−7).

Conclusion

SLC30A8 gene 807C/T polymorphism was significantly associated with an increased T2DM risk in the Chinese population. Therefore, individuals of Chinese descent with the C allele of SLC30A8 gene 807C/T polymorphism may be more susceptible to developing T2DM, while individuals with the T allele may be protected against T2DM.