AUTHOR=Sanjad Sami A. , Aoun Bilal , Yammine Halim , Bassyouni Amina , Karam Pascale E. 

TITLE=Pamidronate Rescue Therapy for Hypercalcemia in a Child With Williams Syndrome

JOURNAL=Frontiers in Endocrinology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2018.00240

DOI=10.3389/fendo.2018.00240

ISSN=1664-2392

ABSTRACT=<p>A 15-month-old male infant diagnosed with Williams Syndrome (WS) was admitted with severe hypercalcemia and nephrocalcinosis. Intravenous hydration and furosemide failed to yield an appreciable and sustainable fall in serum calcium, while the injection of pamidronate achieved a significant decrease in serum calcium in a short period of time. This bisphosphonate could be considered as a second-line treatment for refractory hypercalcemia in WS.</p>