AUTHOR=Mao Yong , Huang Yixiang , Yu Haining , Xu Peng , Yu Guangping , Yu Jinming , Zhan Yiqiang 

TITLE=Incidence of Peripheral Arterial Disease and Its Association with Pulse Pressure: A Prospective Cohort Study

JOURNAL=Frontiers in Endocrinology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2017.00333

DOI=10.3389/fendo.2017.00333

ISSN=1664-2392

ABSTRACT=<sec id="ST1"><title>Background</title><p>The association of pulse pressure and peripheral arterial disease (PAD) has seldom been examined using a prospective design. This study aimed to investigate the association of pulse pressure with PAD incidence in an elderly general population.</p></sec><sec id="ST2"><title>Methods</title><p>We utilized data from a cohort conducted in Beijing with additionally 2-year follow-up time. PAD was defined as an ankle brachial index value &lt;0.9 in either leg. Cox proportional hazard regression model was used to quantify the magnitude of pulse pressure on PAD incidence.</p></sec><sec id="ST3"><title>Results</title><p>During a 2-year follow-up time, 357 of 4,201 (8.5%) participants developed PAD with 105 (6.9%) men and 252 (9.4%) women, respectively. After adjusting for baseline age, sex, body mass index, hypertension, diabetes, total cholesterol, and high-density lipoprotein cholesterol, and smoking, the hazard ratio and 95% confidence interval for people with pulse pressure greater than 60 mmHg was 2.20 (1.53, 3.15) compared with those whose pulse pressure was less than 40 mmHg. A linear trend was observed for the association of pulse pressure with PAD.</p></sec><sec id="ST4"><title>Conclusion</title><p>Higher pulse pressure was associated with higher PAD incidence.</p></sec>