AUTHOR=Felício João Soares , Oliveira Alana Ferreira de , Peixoto Amanda Soares , Souza Ana Carolina Contente Braga de , Abrahão Neto João Felício , de Melo Franciane Trindade Cunha , Carvalho Carolina Tavares , Lemos Manuela Nascimento de , Cavalcante Sávio Diego Nascimento , Resende Fabricio de Souza , Santos Márcia Costa dos , Motta Ana Regina , Janaú Luísa Corrêa , Yamada Elizabeth Sumi , Felício Karem Miléo
TITLE=Albuminuria Reduction after High Dose of Vitamin D in Patients with Type 1 Diabetes Mellitus: A Pilot Study
JOURNAL=Frontiers in Endocrinology
VOLUME=8
YEAR=2017
URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2017.00199
DOI=10.3389/fendo.2017.00199
ISSN=1664-2392
ABSTRACT=BackgroundSome studies suggest an association between diabetic kidney disease (DKD) and vitamin D (VD), but there is no data about the effect of high dose of VD on DKD in type 1 diabetes mellitus (T1DM). Our pilot study aims to evaluate albuminuria reduction in patients with T1DM supplemented with high dose of VD.
Methods22 patients received doses of 4,000 and 10,000 IU/day of cholecalciferol for 12 weeks according to patient’s previous VD levels. They were submitted to continuous glucose monitoring system, 24 hours ambulatory blood pressure monitoring and urine albumin-to-creatinine ratio before and after VD supplementation.
ResultsThere was a reduction of DKD prevalence at the end of the study (68 vs 32%; p = 0.05), with no changes on insulin doses, glycated hemoglobin, glycemic variability and blood pressure values. A correlation between percentage variation of VD levels (ΔVD) and albuminuria at the end of the study was presented (r = −0.5; p < 0.05). Among T1DM patients with DKD at the beginning of the study, 8/13 (62%) had their DKD stage improved, while the other five ones (38%) showed no changes (p < 0.05).
ConclusionOur pilot study suggests an association between VD high dose supplementation, lower prevalence and improvement in stages of DKD in T1DM.