AUTHOR=Sinha Indranil , Sakthivel Dharaniya , Varon David E. 

TITLE=Systemic Regulators of Skeletal Muscle Regeneration in Obesity

JOURNAL=Frontiers in Endocrinology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2017.00029

DOI=10.3389/fendo.2017.00029

ISSN=1664-2392

ABSTRACT=<p>Skeletal muscle maintenance is a dynamic process and undergoes constant repair and regeneration. However, skeletal muscle regenerative capacity declines in obesity. In this review, we focus on obesity-associated changes in inflammation, metabolism, and impaired insulin signaling, which are pathologically dysregulated and ultimately result in a loss of muscle mass and function. In addition, we examine the relationships between skeletal muscle, liver, and visceral adipose tissue in an obese state.</p>