AUTHOR=Sekar Revathi , Wang Lei , Chow Billy Kwok Chong
TITLE=Central Control of Feeding Behavior by the Secretin, PACAP, and Glucagon Family of Peptides
JOURNAL=Frontiers in Endocrinology
VOLUME=8
YEAR=2017
URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2017.00018
DOI=10.3389/fendo.2017.00018
ISSN=1664-2392
ABSTRACT=
Constituting a group of structurally related brain-gut peptides, secretin (SCT), pituitary adenylate cyclase-activating peptide (PACAP), and glucagon (GCG) family of peptide hormones exert their functions via interactions with the class B1 G protein-coupled receptors. In recent years, the roles of these peptides in neuroendocrine control of feeding behavior have been a specific area of research focus for development of potential therapeutic drug targets to combat obesity and metabolic disorders. As a result, some members in the family and their analogs have already been utilized as therapeutic agents in clinical application. This review aims to provide an overview of the current understanding on the important role of SCT, PACAP, and GCG family of peptides in central control of feeding behavior.