AUTHOR=Trumpff Caroline , De Schepper Jean , Vanderfaeillie Johan , Vercruysse Nathalie , Tafforeau Jean , Van Oyen Herman , Vandevijvere Stefanie 

TITLE=No Association between Elevated Thyroid-Stimulating Hormone at Birth and Parent-Reported Problem Behavior at Preschool Age

JOURNAL=Frontiers in Endocrinology

VOLUME=7

YEAR=2016

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2016.00161

DOI=10.3389/fendo.2016.00161

ISSN=1664-2392

ABSTRACT=<sec id="ST1"><title>Objectives</title><p>Mild level of iodine deficiency during pregnancy may reduce maternal thyroid hormone production and supply to the fetus hence affecting brain neurodevelopment. The aim of the present study was to investigate the association between elevated neonatal thyroid-stimulating hormone (TSH) level (&gt;5 mU/L), used as a marker of maternal mild iodine deficiency during late pregnancy, and behavioral development of preschool children.</p></sec><sec id="ST2"><title>Methods</title><p>This retrospective cohort study included 310 Belgian mothers and their children aged 4–5 years old with TSH levels in the range of 0.45–15 mU/L at birth. The TSH level was measured in dried blood spots on filter paper collected by heel stick 3–5 days after birth. Low birth weight, prematurely born children, or children with congenital hypothyroidism were excluded. The degree of behavioral problems was evaluated using the <italic>Child Behavior Check List (CBCL) for age 1½–5 years</italic> questionnaire. Relevant socioeconomic, maternal, and child factors were also collected.</p></sec><sec id="ST3"><title>Results</title><p>TSH concentrations and CBCL scores were not associated both in univariate analysis and when adjusting for confounding factors in multivariate analysis.</p></sec><sec id="ST4"><title>Discussion</title><p>Elevated TSH concentrations measured at birth was not associated with behavioral development scores.</p></sec>