AUTHOR=Adebamowo Sally N. , Adeyemo Adebowale A. , Tekola-Ayele Fasil , Doumatey Ayo P. , Bentley Amy R. , Chen Guanjie , Zhou Jie , Shriner Daniel , Fasanmade Olufemi Adetola , Okafor Godfrey , Eghan Benjamin , Agyenim-Boateng Kofi , Adeleye Jokotade , Balogun Williams , Amoah Albert G. , Owusu Samuel , Acheampong Joseph , Johnson Thomas , Oli Johnnie , Adebamowo Clement A. , Rotimi Charles N. TITLE=Impact of Type 2 Diabetes on Impaired Kidney Function in Sub-Saharan African Populations JOURNAL=Frontiers in Endocrinology VOLUME=7 YEAR=2016 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2016.00050 DOI=10.3389/fendo.2016.00050 ISSN=1664-2392 ABSTRACT=Background

Diabetes is a leading risk factor for impaired kidney function, an indicator of chronic kidney disease. The aim of this study was to examine the association between type 2 diabetes (T2D) and impaired kidney function among adults in sub-Saharan Africa (SSA).

Methods

Participants were enrolled from Ghana, Kenya, and Nigeria. Impaired kidney function was based on an estimated glomerular filtration rate <60 ml/min/1.73 m2. Using logistic regression models, we conducted case–control analyses to estimate the multivariate-adjusted association of T2D and kidney function.

Results

We used data from 4815 participants for whom the mean (SD) age was 48 (15) years, 41% were male and 46% had T2D. Those with T2D were more likely to have impaired kidney function [13.4% (95% CI: 11.9–14.7)] compared to those without T2D [4.8% (95% CI: 4.0–5.6)], p-value <0.001. The multivariate odds ratio of impaired kidney function among those with type 2 diabetes was 1.50 (95% CI: 1.17–1.91) p-value = 0.001, compared to those without T2D. Also, individuals with T2D who were at least 60 years old, obese, hypertensive or dyslipidemic were more likely to have impaired kidney function compared to those without T2D.

Conclusion

T2D was associated with 50% increased risk of impaired kidney function in this sample of adults from SSA. Interventions targeted at prevention, early diagnosis, and management of T2D are likely to reduce the burden of kidney disease in SSA.