AUTHOR=Faienza Maria Felicia , Ventura Annamaria , Colucci Silvia , Cavallo Luciano , Grano Maria , Brunetti Giacomina 

TITLE=Bone Fragility in Turner Syndrome: Mechanisms and Prevention Strategies

JOURNAL=Frontiers in Endocrinology

VOLUME=7

YEAR=2016

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2016.00034

DOI=10.3389/fendo.2016.00034

ISSN=1664-2392

ABSTRACT=<p>Bone fragility is recognized as one of the major comorbidities in Turner syndrome (TS). The mechanisms underlying bone impairment in affected patients are not clearly elucidated, but estrogen deficiency and X-chromosomal abnormalities represent important factors. Moreover, although many girls with TS undergo recombinant growth hormone therapy to treat short stature, the efficacy of this treatment on bone mineral density is controversial. The present review will focus on bone fragility in subjects with TS, providing an overview on the pathogenic mechanisms and some prevention strategies.</p>