AUTHOR=Orellana Ana Maria , Kinoshita Paula Fernanda , Leite Jacqueline Alves , Kawamoto Elisa Mitiko , Scavone Cristoforo TITLE=Cardiotonic Steroids as Modulators of Neuroinflammation JOURNAL=Frontiers in Endocrinology VOLUME=7 YEAR=2016 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2016.00010 DOI=10.3389/fendo.2016.00010 ISSN=1664-2392 ABSTRACT=

Cardiotonic steroids (CTS) are a class of specific ligands of the Na+, K+- ATPase (NKA). NKA is a P-type ATPase that is ubiquitously expressed and although well known to be responsible for the maintenance of the cell electrochemical gradient through active transport, NKA can also act as a signal transducer in the presence of CTS. Inflammation, in addition to importantly driving organism defense and survival mechanisms, can also modulate NKA activity and memory formation, as well as being relevant to many chronic illnesses, neurodegenerative diseases, and mood disorders. The aim of the current review is to highlight the recent advances as to the role of CTS and NKA in inflammatory process, with a particular focus in the central nervous system.