AUTHOR=Kremer Richard , Gilsanz Vicente 

TITLE=Fat and Bone: An Odd Couple

JOURNAL=Frontiers in Endocrinology

VOLUME=6

YEAR=2016

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2015.00190

DOI=10.3389/fendo.2015.00190

ISSN=1664-2392

ABSTRACT=<p>In this review, we will first discuss the concept of bone strength and introduce how fat at different locations, including the bone marrow, directly or indirectly regulates bone turnover. We will then review the current literature supporting the mechanistic relationship between marrow fat and bone and our understanding of the relationship between body fat, body weight, and bone with emphasis on its hormonal regulation. Finally, we will briefly discuss the importance and challenges of accurately measuring the fat compartments using non-invasive methods. This review highlights the complex relationship between fat and bone and how these new concepts will impact our diagnostic and therapeutic approaches in the very near future.</p>