AUTHOR=Jiang Chunhui , Kuang Liangju , Merkel Madeline P., Yue Feng , Cano-Vega Mario A., Narayanan Naagarajan , Kuang Shihuan , Deng Meng TITLE=Biodegradable polymeric microsphere-based drug delivery for inductive browning of fat JOURNAL=Frontiers in Endocrinology VOLUME=6 YEAR=2015 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2015.00169 DOI=10.3389/fendo.2015.00169 ISSN=1664-2392 ABSTRACT=
Brown and beige adipocytes are potent therapeutic agents to increase energy expenditure and reduce risks of obesity and its affiliated metabolic symptoms. One strategy to increase beige adipocyte content is through inhibition of the evolutionarily conserved Notch signaling pathway. However, systemic delivery of Notch inhibitors is associated with off-target effects and multiple dosages of application further faces technical and translational challenges. Here, we report the development of a biodegradable polymeric microsphere-based drug delivery system for sustained, local release of a Notch inhibitor, DBZ. The microsphere-based delivery system was fabricated and optimized using an emulsion/solvent evaporation technique to encapsulate DBZ into poly(lactide-