AUTHOR=Thanasupawat Thatchawan , Glogowska Aleksandra , Burg Maxwell , Wong G. William , Hoang-Vu Cuong , Hombach-Klonisch Sabine , Klonisch Thomas 

TITLE=RXFP1 is Targeted by Complement C1q Tumor Necrosis Factor-Related Factor 8 in Brain Cancer

JOURNAL=Frontiers in Endocrinology

VOLUME=6

YEAR=2015

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2015.00127

DOI=10.3389/fendo.2015.00127

ISSN=1664-2392

ABSTRACT=<p>The relaxin-like RXFP1 ligand–receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/tumor necrosis factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor, RXFP1, with functions in brain cancer. Here, we review the role of CTRP members in cancers cells with particular emphasis on CTRP8 in glioblastoma.</p>