AUTHOR=Gianchandani Roma Y. , Saberi Sima , Patil Preethi , Prager Richard L. , Pop-Busui Rodica 

TITLE=Prevalence and Determinants of Glycemic Abnormalities in Cardiac Surgery Patients without a History of Diabetes: A Prospective Study

JOURNAL=Frontiers in Endocrinology

VOLUME=6

YEAR=2015

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2015.00125

DOI=10.3389/fendo.2015.00125

ISSN=1664-2392

ABSTRACT=<sec id="ST1"><title>Objective</title><p>To evaluate the prevalence and persistence of postoperative glycemic abnormalities in patients without a history of diabetes, undergoing cardiac surgery (CS).</p></sec><sec id="ST2"><title>Methods</title><p>Ninety-two patients without diabetes with planned elective CS procedures at a tertiary institution were evaluated preoperatively and 3 months postoperatively for measures of glucose control including hemoglobin A1c, fasting plasma glucose, 2-h post oral glucose load, and insulin levels. Data from the hospital course were recorded.</p></sec><sec id="ST3"><title>Results</title><p>Valid data were available from 61 participants at 3 months; 59% had prediabetes and 10% had diabetes preoperatively by one or more diagnostic criteria and continued to be dysglycemic at 3 months. Preoperative A1C was an independent predictor of postoperative hyperglycemia (<italic>p</italic> = 0.02). Insulin resistance and BMI rather than glycemic abnormalities before surgery were associated with a longer duration of the postoperative insulin infusion (<italic>p</italic> = 0.004, <italic>p</italic> = 0.048).</p></sec><sec id="ST4"><title>Conclusion</title><p>Seventy percent of CS patients without known diabetes met criteria for diabetes or prediabetes preoperatively, and these abnormalities persisted after surgery.</p></sec>