AUTHOR=Ruiz-Babot Gerard , Hadjidemetriou Irene , King Peter James , Guasti Leonardo 

TITLE=New Directions for the Treatment of Adrenal Insufficiency

JOURNAL=Frontiers in Endocrinology

VOLUME=6

YEAR=2015

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2015.00070

DOI=10.3389/fendo.2015.00070

ISSN=1664-2392

ABSTRACT=<p>Adrenal disease, whether primary, caused by defects in the hypothalamic–pituitary–adrenal (HPA) axis, or secondary, caused by defects outside the HPA axis, usually results in adrenal insufficiency, which requires lifelong daily replacement of corticosteroids. However, this kind of therapy is far from ideal as physiological demand for steroids varies considerably throughout the day and increases during periods of stress. The development of alternative curative strategies is therefore needed. In this review, we describe the latest technologies aimed at either isolating or generating <italic>de novo</italic> cells that could be used for novel, regenerative medicine application in the adrenocortical field.</p>