AUTHOR=Cahoreau Claire , Klett Danièle , Combarnous Yves TITLE=Structure–Function Relationships of Glycoprotein Hormones and Their Subunits’ Ancestors JOURNAL=Frontiers in Endocrinology VOLUME=6 YEAR=2015 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2015.00026 DOI=10.3389/fendo.2015.00026 ISSN=1664-2392 ABSTRACT=

Glycoprotein hormones (GPHs) are the most complex molecules with hormonal activity. They exist only in vertebrates but the genes encoding their subunits’ ancestors are found in most vertebrate and invertebrate species although their roles are still unknown. In the present report, we review the available structural and functional data concerning GPHs and their subunits’ ancestors.