AUTHOR=Pickard Adam , McCance Dennis J. 

TITLE=IGF-Binding Protein 2 – Oncogene or Tumor Suppressor?

JOURNAL=Frontiers in Endocrinology

VOLUME=6

YEAR=2015

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2015.00025

DOI=10.3389/fendo.2015.00025

ISSN=1664-2392

ABSTRACT=<p>The role of insulin-like growth factor binding protein 2 (IGFBP2) in cancer is unclear. In general, IGFBP2 is considered to be oncogenic and its expression is often observed to be elevated in cancer. However, there are a number of conflicting reports <italic>in vitro</italic> and <italic>in vivo</italic> where IGFBP2 acts in a tumor suppressor manner. In this mini-review, we discuss the factors influencing the variation in IGFBP2 expression in cancer and our interpretation of these findings.</p>