AUTHOR=Di Donato Marzia , Giovannelli Pia , Cernera Gustavo , Di Santi Annalisa , Marino Irene , Bilancio Antonio , Galasso Giovanni , Auricchio Ferdinando , Migliaccio Antimo , Castoria Gabriella TITLE=Non-Genomic Androgen Action Regulates Proliferative/Migratory Signaling in Stromal Cells JOURNAL=Frontiers in Endocrinology VOLUME=5 YEAR=2015 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2014.00225 DOI=10.3389/fendo.2014.00225 ISSN=1664-2392 ABSTRACT=

Prostate cancer (PCa) is the major cause of cancer-related death among the male population of Western society, and androgen-deprivation therapy (ADT) represents the first line in PCa treatment. However, although androgen receptor (AR) expression is maintained throughout the various stages of PCa, ADT frequently fails. Clinical studies have demonstrated that different androgen/AR signaling pathways operate in target tissues. AR stimulates growth and transformation of target cells, but under certain conditions slows down their proliferation. In this review, we discuss the role of AR in controlling different functions of mesenchymal and transformed mesenchymal cells. Findings here presented support the role of AR in suppressing proliferation and stimulating migration of stromal cells, with implications for current approaches to cancer therapy.