AUTHOR=Gonick Harvey C. 

TITLE=Evidence for a 12 kDa “Carrier Protein” for Natriuretic Hormone

JOURNAL=Frontiers in Endocrinology

VOLUME=5

YEAR=2014

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2014.00196

DOI=10.3389/fendo.2014.00196

ISSN=1664-2392

ABSTRACT=<p>The search for the elusive Na-K-ATPase-inhibiting natriuretic hormone continues. In this review, evidence is presented that isolating the carrier protein for natriuretic hormone from hypertensive plasma is a necessary first step before splitting off the final hormone. The carrier protein has a molecular weight of 12 kDa while the final hormone has a molecular weight of 408 Da. Both compounds inhibit Na-K-ATPase but the compound containing the carrier protein predominates. The question has been raised as to whether the carrier protein is in actuality proANF, a 17 kDa protein that can be split between a 14 kDa protein (the presumptive proANF) and the 3 kDa ANF.</p>