AUTHOR=Teng Beina , Duong Michelle , Tossidou Irini , Yu Xuejiao , Schiffer Mario 

TITLE=Role of Protein Kinase C in Podocytes and Development of Glomerular Damage in Diabetic Nephropathy

JOURNAL=Frontiers in Endocrinology

VOLUME=5

YEAR=2014

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2014.00179

DOI=10.3389/fendo.2014.00179

ISSN=1664-2392

ABSTRACT=<p>The early glomerular changes in diabetes include a podocyte phenotype with loss of slit diaphragm proteins, changes in the actin cytoskeleton and foot process architecture. This review focuses on the role of the protein kinase C (PKC) family in podocytes and points out the differential roles of classical, novel, and atypical PKCs in podocytes. Some PKC isoforms are indispensable for proper glomerular development and slit diaphragm maintenance, whereas others might be harmful when activated in the diabetic milieu. Therefore, some might be interesting treatment targets in the early phase of diabetes.</p>