AUTHOR=Grasso Daniel , Vaccaro Maria I. 

TITLE=Macroautophagy and the Oncogene-Induced Senescence

JOURNAL=Frontiers in Endocrinology

VOLUME=5

YEAR=2014

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2014.00157

DOI=10.3389/fendo.2014.00157

ISSN=1664-2392

ABSTRACT=<p>The oncogene-induced senescence is emerging as a potent tumor suppressor mechanism and as a possible therapeutic target. Macroautophagy is intimately linked to the senescence condition setup, although its role has not been elucidated yet. Here, we discuss up-to-date concepts of senescence-related macroautophagy and evaluate the current trend of this growing research field, which has relevance in future perspectives toward therapeutic options against cancer.</p>