AUTHOR=Gubar Olga , Morderer Dmytro , Tsyba Lyudmila , Croisé Pauline , Houy Sébastien , Ory Stéphane , Gasman Stephane , Rynditch Alla 

TITLE=Intersectin: The Crossroad between Vesicle Exocytosis and Endocytosis

JOURNAL=Frontiers in Endocrinology

VOLUME=4

YEAR=2013

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2013.00109

DOI=10.3389/fendo.2013.00109

ISSN=1664-2392

ABSTRACT=<p>Intersectins (ITSNs) are a family of highly conserved proteins with orthologs from nematodes to mammals. In vertebrates, ITSNs are encoded by two genes (<italic>itsn1</italic> and <italic>itsn2</italic>), which act as scaffolds that were initially discovered as proteins involved in endocytosis. Further investigation demonstrated that ITSN1 is also implicated in several other processes including regulated exocytosis, thereby suggesting a role for ITSN1 in the coupling between exocytosis and endocytosis in excitatory cells. Despite a high degree of conservation amongst orthologs, ITSN function is not so well preserved as they have acquired new properties during evolution. In this review, we will discuss the role of ITSN1 and its orthologs in exo- and endocytosis, in particular in neurons and neuroendocrine cells.</p>