AUTHOR=Ng Stephanie Y., Lee Leo T., Chow Billy K.

TITLE=Receptor oligomerization: from early evidence to current understanding in class B GPCRs

JOURNAL=Frontiers in Endocrinology

VOLUME=3

YEAR=2013

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2012.00175

DOI=10.3389/fendo.2012.00175

ISSN=1664-2392

ABSTRACT=<p>Dimerization or oligomerization of G protein-coupled receptors (GPCRs) are known to modulate receptor functions in terms of ontogeny, ligand-oriented regulation, pharmacological diversity, signal transduction, and internalization. Class B GPCRs are receptors to a family of hormones including secretin, growth hormone-releasing hormone, vasoactive intestinal polypeptide and parathyroid hormone, among others. The functional implications of receptor dimerization have extensively been studied in class A GPCRs, while less is known regarding its function in class B GPCRs. This article reviews receptor oligomerization in terms of the early evidence and current understanding particularly of class B GPCRs.</p>