AUTHOR=Cohen-Tannoudji Joelle , Avet Charlotte , Garrel Ghislaine , Counis raymond , Simon Violaine TITLE=Decoding high Gonadotropin-releasing hormone pulsatility: a role for GnRH receptor coupling to the cAMP pathway? JOURNAL=Frontiers in Endocrinology VOLUME=3 YEAR=2012 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2012.00107 DOI=10.3389/fendo.2012.00107 ISSN=1664-2392 ABSTRACT=
The gonadotropin-releasing hormone (GnRH) pulsatile pattern is critical for appropriate regulation of gonadotrope activity but only little is known about the signaling mechanisms by which gonadotrope cells decode such pulsatile pattern. Here, we review recent lines of evidence showing that the GnRH receptor (GnRH-R) activates the cyclic AMP (cAMP) pathway in gonadotrope cells, thus ending a long-lasting controversy. Interestingly, coupling of GnRH-R to the cAMP pathway as well as induction of nitric oxide synthase 1 (NOS1) or follistatin through this signaling pathway take place preferentially under high GnRH pulsatility. The preovulatory surge of GnRH