AUTHOR=Rewitz Kim F., O'Connor Michael B.

TITLE=Timing is Everything: PTTH Mediated DHR4 Nucleocytoplasmic Trafficking Sets the Tempo of Drosophila Steroid Production

JOURNAL=Frontiers in Endocrinology

VOLUME=2

YEAR=2011

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2011.00108

DOI=10.3389/fendo.2011.00108

ISSN=1664-2392

ABSTRACT=<p>During development, multicellular organisms must become sexually mature in order to reproduce. The developmental timing of this transition is controlled by pulses of steroid hormones, but how these pulses are generated have remained unclear? A recent paper shows that in <italic>Drosophila</italic> larvae, nucleocytoplasmic trafficking of DHR4, a nuclear receptor, in response to prothoracicotropic hormone signaling, is critical for producing the correct temporal pulses of steroid hormones that coordinate the juvenile–adult transition.</p>