AUTHOR=Rewitz Kim F., O'Connor Michael B.

TITLE=Timing is Everything: PTTH Mediated DHR4 Nucleocytoplasmic Trafficking Sets the Tempo of Drosophila Steroid Production

JOURNAL=Frontiers in Endocrinology

VOLUME=volume 2 - 2011

YEAR=2011

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2011.00108

DOI=10.3389/fendo.2011.00108

ISSN=1664-2392

ABSTRACT=During development multicellular organisms must become sexually mature to reproduce. But what underlying developmental clock times this transition?   Recent data shows that in fly larvae, nuclear-cytoplasmic trafficking of DHR4, a nuclear receptor, in response to Prothoraciotropic hormone (PTTH) signaling is critical for producing the correct temporal pulses of steroid hormones that coordinate the juvenile-adult transition.