AUTHOR=Melcangi Roberto Cosimo , Giatti Silvia , Pesaresi Marzia , Carabrese Donato , Mitro Nico , Caruso Donatella , Garcia-Segura Luis M. TITLE=Role of Neuroactive Steroids in the Peripheral Nervous System JOURNAL=Frontiers in Endocrinology VOLUME=2 YEAR=2011 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2011.00104 DOI=10.3389/fendo.2011.00104 ISSN=1664-2392 ABSTRACT=

Several reviews have so far pointed out on the relevant physiological and pharmacological role exerted by neuroactive steroids in the central nervous system. In the present review we summarize observations indicating that synthesis and metabolism of neuroactive steroids also occur in the peripheral nerves. Interestingly, peripheral nervous system is also a target of their action. Indeed, as here reported neuroactive steroids are physiological regulators of peripheral nerve functions and they may also represent interesting therapeutic tools for different types of peripheral neuropathy.