AUTHOR=Ma Lifeng , Wang Rui , Feng Siwei , Yang Xiaomin , Li Jing , Zhang Zhiying , Zhan Haoshuang , Wang Yao , Xia Ziyang , Wang Chuan-Chao , Kang Longli TITLE=Genomic insight into the population history and biological adaptations of high-altitude Tibetan highlanders in Nagqu JOURNAL=Frontiers in Ecology and Evolution VOLUME=10 YEAR=2022 URL=https://www.frontiersin.org/journals/ecology-and-evolution/articles/10.3389/fevo.2022.930840 DOI=10.3389/fevo.2022.930840 ISSN=2296-701X ABSTRACT=
Tibetan, one of the largest indigenous populations living in the high-altitude region of the Tibetan Plateau (TP), has developed a suite of physiological adaptation strategies to cope with the extreme highland environment in TP. Here, we reported genome-wide SNP data from 48 Kham-speaking Nagqu Tibetans and analyzed it with published data from 1,067 individuals in 167 modern and ancient populations to characterize the detailed Tibetan subgroup history and population substructure. Overall, the patterns of allele sharing and haplotype sharing suggested (1) the relatively genetic homogeny between the studied Nagqu Tibetans and ancient Nepalese as well as present-day core Tibetans from Lhasa, Nagqu, and Shigatse; and (2) the close relationship between our studied Kham-speaking Nagqu Tibetans and Kham-speaking Chamdo Tibetans. The fitted