AUTHOR=Layton Deborah , Hester Laura , Golozar Asieh TITLE=Editorial: External control arms for single-arm studies: methodological considerations and applications JOURNAL=Frontiers in Drug Safety and Regulation VOLUME=5 YEAR=2025 URL=https://www.frontiersin.org/journals/drug-safety-and-regulation/articles/10.3389/fdsfr.2025.1579171 DOI=10.3389/fdsfr.2025.1579171 ISSN=2674-0869