Frontiers in Drug Discovery

Volume 5 - 2025

Original Research

Accepted on 21 Apr 2025

Safety and tolerability of the treatment with a bevacizumab biosimilar (Effivia ® ) in adult Mexican patients with cancer: a multicenter, observational, prospective clinical study

Alberto Alfonso Pimentel-Rentería
David Cantu
Eliseo Neftalí De La Cruz
David Suárez
Manuel Rodulfo Segura
José Gustavo Núñez
Livan Delgado-Roche

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1591991

Original Research

Published on 15 Apr 2025

Identification of natural compounds as potential inhibitors of Interleukin-23: virtual screening, ADMET, drug-likeness, and dynamic simulation

Davood Gheidari
Morteza Mehrdad
Mahan Etedali

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1525533

309 views

Original Research

Published on 21 Feb 2025

Transduction of hematopoietic stem and progenitor cells by an MECP2 lentiviral vector improves Rett syndrome phenotypes

Joseph S. Anderson
Jill L. Silverman
Alyse L. Lodigiani
Camilla M. Barbaduomo
Julie R. Beegle

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1545391

537 views

Editorial

Published on 20 Feb 2025

Editorial: Exploring drug development with single cell omics analytics and stem cell-based disease models

Linheng Li
Fuchou Tang
Hongkui Deng

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1561985

336 views

Perspective

Published on 19 Feb 2025

Perspective: How complex in vitro models are addressing the challenges of predicting drug-induced liver injury

K. Taylor
R. Ram
L. Ewart
C. Goldring
G. Russomanno
G. P. Aithal
T. Kostrzewski
C. Bauch
J. M. Wilkinson
S. Modi

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1536756

2,063 views

Review

Published on 29 Jan 2025

Non-enzymatic protein targeting agents as a promising strategy for cancer treatment

Madison Ambrose
Jeremy Lee
Aleem Syed
Zamal Ahmed
Guang Peng

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1520734

1,285 views

Volume 4 - 2024

Original Research

Published on 03 Jan 2025

Validation of an MPS-based intestinal cell culture model for the evaluation of drug-induced toxicity

Stefanie Hoffmann
Philip Hewitt
Isabel Koscielski
Dorota Kurek
Wouter Strijker
Kinga Kosim

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1459424

1,377 views

Review

Published on 19 Dec 2024

Targeting steroid receptor coactivators in cancer via small molecule agents

Yosi Gilad
Ortal Shimon
David M. Lonard
Bert W. O’Malley

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1514412

557 views

Editorial

Published on 29 Nov 2024

Editorial: Drug discovery and development explained: introductory notes for the general public

Bruno O. Villoutreix
Jean-Luc Poyet
Katya Tsaioun

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1528467

1,123 views

Review

Published on 19 Nov 2024

Decoding lung complexity: single-cell sequencing in lung diseases, regeneration, and drug discovery

Peng Wang
Nan Tang

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1495208

906 views

Original Research

Published on 29 Oct 2024

Drug–drug interaction extraction based on multimodal feature fusion by Transformer and BiGRU

Changqing Yu
Shanwen Zhang
Xuqi Wang
Tailong Shi
Chen Jiang
Sizhe Liang
Guanghao Ma

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1460672

650 views

Review

Published on 22 Oct 2024

Single-cell multiomics: a new frontier in drug research and development

Jiaxiu Ma
Chao Dong
Aibin He
Haiqing Xiong

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1474331

1,807 views

Review

Published on 18 Oct 2024

Single-cell technology for drug discovery and development

Anzhuo Zhang
Jiawei Zou
Yue Xi
Lianchong Gao
Fulan Deng
Yujun Liu
Pengfei Gao
Henry H. Y. Tong
Lianjiang Tan
Xin Zou

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1459962

2,973 views

Review

Published on 16 Oct 2024

Metal-antimicrobial peptides combo: promising weapons to combat bacteria invaders

Lucia Falcigno
Simone Braccia
Rosa Bellavita
Gabriella D’Auria
Annarita Falanga
Stefania Galdiero

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1440378

1,187 views
1 citation

Brief Research Report

Published on 07 Oct 2024

Brief research report: Transcriptional blockade of angiotensin converting enzyme 2 modelled in human retinal pigment epithelial cells

Liam M. Ashander
Amanda L. Lumsden
Yuefang Ma
Alwin Chun Rong Tan
Binoy Appukuttan
Santhosh Daniel
Michael Z. Michael
Justine R. Smith

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1416728

595 views

Original Research

Published on 02 Oct 2024

Artificial intelligence driven image analysis identifies phenobarbital induced hepatocyte hypertrophy in liver microtissues across species

Matthew Elcombe
Ayesha Mathur
Stephanie Wallace
Jayne Wright
Simon Plummer

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1472522

1,117 views