Frontiers in Drug Discovery

Original Research

Accepted on 06 Feb 2025

Transduction of Hematopoietic Stem and Progenitor Cells By an MECP2 Lentiviral Vector Improves Rett Syndrome Phenotypes

in Neurological Drugs

Joseph S Anderson
Jill L Silverman
Alyse L Lodigiani
Camilla M Barbaduomo
Julie R Beegle

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1545391

Review

Published on 29 Jan 2025

Non-enzymatic protein targeting agents as a promising strategy for cancer treatment

in Anti-Cancer Drugs

Madison Ambrose
Jeremy Lee
Aleem Syed
Zamal Ahmed
Guang Peng

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1520734

365 views

Perspective

Accepted on 24 Jan 2025

Perspective: How complex in vitro models (CIVMs) are addressing the challenges of predicting drug induced liver injury (DILI)

in Technologies and Strategies to Enable Drug Discovery

Katy Taylor
Rebecca Ram
Lorna Ewart
Chris Goldring
Giusy Russomanno
Guruprasad Padur Aithal
Tomasz Kostrzewski
Caroline Bauch
John Malcolm Wilkinson
Stephanie Modi

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1536756

Editorial

Accepted on 21 Jan 2025

Advancing Drug Discovery Using Single Cell Multiomics with Stem Cell Platform

in Technologies and Strategies to Enable Drug Discovery

Linheng Li
Fuchou Tang
HongkuiHongkui Deng

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1561985

Original Research

Published on 03 Jan 2025

Validation of an MPS-based intestinal cell culture model for the evaluation of drug-induced toxicity

in Technologies and Strategies to Enable Drug Discovery

Stefanie Hoffmann
Philip Hewitt
Isabel Koscielski
Dorota Kurek
Wouter Strijker
Kinga Kosim

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1459424

436 views

Review

Published on 19 Dec 2024

Targeting steroid receptor coactivators in cancer via small molecule agents

in Anti-Cancer Drugs

Yosi Gilad
Ortal Shimon
David M. Lonard
Bert W. O’Malley

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1514412

300 views

Editorial

Published on 29 Nov 2024

Editorial: Drug discovery and development explained: introductory notes for the general public

in Technologies and Strategies to Enable Drug Discovery

Bruno O. Villoutreix
Jean-Luc Poyet
Katya Tsaioun

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1528467

670 views

Review

Published on 19 Nov 2024

Decoding lung complexity: single-cell sequencing in lung diseases, regeneration, and drug discovery

in Technologies and Strategies to Enable Drug Discovery

Peng Wang
Nan Tang

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1495208

575 views

Original Research

Published on 29 Oct 2024

Drug–drug interaction extraction based on multimodal feature fusion by Transformer and BiGRU

in In silico Methods and Artificial Intelligence for Drug Discovery

Changqing Yu
Shanwen Zhang
Xuqi Wang
Tailong Shi
Chen Jiang
Sizhe Liang
Guanghao Ma

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1460672

411 views

Review

Published on 22 Oct 2024

Single-cell multiomics: a new frontier in drug research and development

in Technologies and Strategies to Enable Drug Discovery

Jiaxiu Ma
Chao Dong
Aibin He
Haiqing Xiong

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1474331

1,243 views

Review

Published on 18 Oct 2024

Single-cell technology for drug discovery and development

in Technologies and Strategies to Enable Drug Discovery

Anzhuo Zhang
Jiawei Zou
Yue Xi
Lianchong Gao
Fulan Deng
Yujun Liu
Pengfei Gao
Henry H. Y. Tong
Lianjiang Tan
Xin Zou

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1459962

1,807 views

Review

Published on 16 Oct 2024

Metal-antimicrobial peptides combo: promising weapons to combat bacteria invaders

in Anti-Infective Agents

Lucia Falcigno
Simone Braccia
Rosa Bellavita
Gabriella D’Auria
Annarita Falanga
Stefania Galdiero

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1440378

667 views

Brief Research Report

Published on 07 Oct 2024

Brief research report: Transcriptional blockade of angiotensin converting enzyme 2 modelled in human retinal pigment epithelial cells

in Technologies and Strategies to Enable Drug Discovery

Liam M. Ashander
Amanda L. Lumsden
Yuefang Ma
Alwin Chun Rong Tan
Binoy Appukuttan
Santhosh Daniel
Michael Z. Michael
Justine R. Smith

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1416728

416 views

Original Research

Published on 02 Oct 2024

Artificial intelligence driven image analysis identifies phenobarbital induced hepatocyte hypertrophy in liver microtissues across species

in Technologies and Strategies to Enable Drug Discovery

Matthew Elcombe
Ayesha Mathur
Stephanie Wallace
Jayne Wright
Simon Plummer

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1472522

836 views

Mini Review

Published on 02 Oct 2024

The role of the HIV-1 gut reservoir in driving early cardiovascular events in people living with HIV

in Anti-inflammatory and Immunomodulating Agents

Keri Kramer
Amanda Michael
Guadalupe Quiñones
Sebastian Roa
Susan P. Ribeiro
Cecile D. Lahiri
Christina Gavegnano

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1334307

551 views

Review

Published on 30 Sep 2024

Combating cancer stem cells: RNA m6A methylation and small-molecule drug discovery

in Anti-Cancer Drugs

Honghai Zhang
Xueer Wang
Jianjun Chen
Rui Su

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1465222

782 views

Navigation group

Articles

Transduction of Hematopoietic Stem and Progenitor Cells By an MECP2 Lentiviral Vector Improves Rett Syndrome Phenotypes

Non-enzymatic protein targeting agents as a promising strategy for cancer treatment

Perspective: How complex in vitro models (CIVMs) are addressing the challenges of predicting drug induced liver injury (DILI)

Advancing Drug Discovery Using Single Cell Multiomics with Stem Cell Platform

Validation of an MPS-based intestinal cell culture model for the evaluation of drug-induced toxicity

Targeting steroid receptor coactivators in cancer via small molecule agents

Editorial: Drug discovery and development explained: introductory notes for the general public

Decoding lung complexity: single-cell sequencing in lung diseases, regeneration, and drug discovery

Drug–drug interaction extraction based on multimodal feature fusion by Transformer and BiGRU

Single-cell multiomics: a new frontier in drug research and development

Single-cell technology for drug discovery and development

Metal-antimicrobial peptides combo: promising weapons to combat bacteria invaders

Brief research report: Transcriptional blockade of angiotensin converting enzyme 2 modelled in human retinal pigment epithelial cells

Artificial intelligence driven image analysis identifies phenobarbital induced hepatocyte hypertrophy in liver microtissues across species

The role of the HIV-1 gut reservoir in driving early cardiovascular events in people living with HIV

Combating cancer stem cells: RNA m6A methylation and small-molecule drug discovery