AUTHOR=Poligone Brian , Alexander-Savino Carolina V. , Kim Ellen J. , Mangold Aaron R. , Desimone Jennifer , Wong Henry K. , Rumage Adam T. , Donini Oreola , Haulenbeek Andrea , Schaber Christopher J. , Straube Richard , Pullion Christopher , Rook Alain H. TITLE=HyBryte™ use in early-stage cutaneous T-cell lymphoma JOURNAL=Frontiers in Drug Discovery VOLUME=3 YEAR=2023 URL=https://www.frontiersin.org/journals/drug-discovery/articles/10.3389/fddsv.2023.1298453 DOI=10.3389/fddsv.2023.1298453 ISSN=2674-0338 ABSTRACT=

Cutaneous T-cell lymphoma (CTCL) is a rare type of non-Hodgkin lymphoma of the skin, where at later stages skin-homing malignant T-cells affect lymph nodes, blood, and visceral organs. Even though early CTCL does not affect survival, it can progress to more advanced stages of disease and have a significant effect on the quality of life of patients. Although expectant management is a treatment consideration in early disease stages, most patients cycle through different skin-directed therapies throughout their lifetime. It can become a challenge to manage the serious and accumulating risk of side effects of these therapies, including various skin cancers and skin damage. Adverse effects from topical therapies limit their long-term utility. Thus, there is an unmet need for well-characterized therapies that have a rapid onset of action and minimal long-term/cumulative side effect profile. Most recently, the results of a Phase 3 study of topical HyBryte™ as a potential treatment for CTCL demonstrated its efficacy and safety profile. This article summarizes what is known about HyBryte™, focuses on its mechanism of action, and highlights its effectiveness, safety, and tolerability in the context of other current FDA-approved topical therapies for CTCL.