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REVIEW article

Front. Drug Deliv.
Sec. Technological and Methodological Advances in Drug Delivery
Volume 4 - 2024 | doi: 10.3389/fddev.2024.1436842

Strategies and Delivery Systems for Cell-Based Therapy in Autoimmunity

Provisionally accepted

The final, formatted version of the article will be published soon.

    This review article explores the potential of engineering antigen-presenting cells (APCs) for the immunotherapy of autoimmune diseases. It discusses various strategies for modifying APCs to induce antigen-specific tolerance, thereby mitigating autoimmune responses. The review covers recent advancements in APC engineering techniques, including genetic modification and nanoparticle-based approaches, and evaluates their efficacy in preclinical models and clinical trials. Additionally, challenges and future directions for the development of APC-based immunotherapies for autoimmunity -and other forms of cellbased immunotherapy -are discussed. Along this direction, this review (i) describes various strategies for engineering APCs, including genetic modification, nanoparticle delivery systems, and ex vivo manipulation techniques; (ii) discusses the selection of target antigens and the design of APC-based immunotherapies, and (iii) reviews preclinical models used to evaluate the efficacy and safety of engineered APCs in inducing antigen-specific tolerance.

    Keywords: Immunotherapy, Antigen-Presenting Cells, Autoimmunity, Genetic Engineering, Nanoparticles

    Received: 22 May 2024; Accepted: 26 Jul 2024.

    Copyright: © 2024 Puccetti, Costantini, Schoubben, Giovagnoli and Ricci. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Matteo Puccetti, University of Perugia, Perugia, Italy
    Maurizio Ricci, University of Perugia, Perugia, Italy

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.