AUTHOR=Buchete Nicolae-Viorel , Cicha Iwona , Dutta Sutapa , Neofytou Panagiotis 

TITLE=Multiscale physics-based in silico modelling of nanocarrier-assisted intravascular drug delivery

JOURNAL=Frontiers in Drug Delivery

VOLUME=4

YEAR=2024

URL=https://www.frontiersin.org/journals/drug-delivery/articles/10.3389/fddev.2024.1362660

DOI=10.3389/fddev.2024.1362660

ISSN=2674-0850

ABSTRACT=<p>A rational design of drug nanocarriers supported by <italic>in silico</italic> modelling tools can improve the efficacy of nanosystem-based intravascular drug delivery (IVDD). Computational model development stems from the vision of replacing conventional (pre)clinical trials with advanced simulations and applies to the development of more efficient nanocarriers for intravascular therapies. To establish a standardized framework for <italic>in silico</italic> preclinical trials, it is necessary to include <italic>in silico</italic> tools that can model each experimental stage of a preclinical trial for a respective nanocarrier system and give accurate and verifiable results. This review paper highlights the status of intravascular drug delivery supported by nanocarriers and discusses the modelling stages of a physics-based multiscale modelling framework that should be developed, validated and exploited to address the need for an effective preclinical assessment of nanocarriers for IVDD.</p>