AUTHOR=Mohite Popat , Singh Sudarshan , Pawar Anil , Sangale Adinath , Prajapati Bhupendra G. TITLE=Lipid-based oral formulation in capsules to improve the delivery of poorly water-soluble drugs JOURNAL=Frontiers in Drug Delivery VOLUME=3 YEAR=2023 URL=https://www.frontiersin.org/journals/drug-delivery/articles/10.3389/fddev.2023.1232012 DOI=10.3389/fddev.2023.1232012 ISSN=2674-0850 ABSTRACT=

Poorly water-soluble drugs demonstrate significant challenge in pharmaceutical development, which is linked to their limited oral bioavailability and therapeutic efficacy. To overcome these limitations, lipid-based formulations have emerged as a promising approach to enhance the delivery of such drugs. Moreover, encapsulation within capsules to provide a convenient dosage form for oral administration. The encapsulation techniques are optimized to ensure uniform drug content and efficient encapsulation efficiency. Several investigations demonstrated that the lipid-based formulations in capsules significantly improved the solubility and dissolution rate of poorly water-soluble drugs compared to non-lipid formulations. Additionally, the encapsulation of lipid-based formulations protected the drug against degradation and improved its stability. Overall, incorporating lipid-based formulations in capsules represents a promising strategy for enhancing the delivery of poorly water-soluble drugs with improvement in solubility, dissolution, stability, and bioavailability, overcoming the challenges associated with these challenging drug molecules. The review focussed a brief on utilization of lipids in capsule form to improve therapeutic efficacy of poorly soluble, dissolution and bioavailability of drugs.