AUTHOR=Dardet Jean Paul , Serrano Nelson , András Ibolya Edit , Toborek Michal 

TITLE=Overcoming Blood-Brain Barrier Resistance: Implications for Extracellular Vesicle-Mediated Drug Brain Delivery

JOURNAL=Frontiers in Drug Delivery

VOLUME=2

YEAR=2022

URL=https://www.frontiersin.org/journals/drug-delivery/articles/10.3389/fddev.2022.855017

DOI=10.3389/fddev.2022.855017

ISSN=2674-0850

ABSTRACT=<p>Drug delivery across the blood–brain barrier (BBB) has several challenges, especially toward targeting neurological diseases, due to tight and selective barrier function of the BBB. Several structural and functional components of this barrier contribute to restricting drug entry, such as interendothelial tight junctions (TJs), efflux transporters, drug-metabolizing enzymes, and crosstalk between the cells of the neurovascular unit. Among different strategies to overcome BBB resistance to therapeutic drug delivery, the use of extracellular vesicles (EVs) gained attention in recent years. This review discusses the BBB structural and functional resistance, as well as potential avenues to overcome this challenge using EVs as drug delivery vehicles into the brain.</p>