David C. Mohr ^1,2* Alexandra Silverman ^2,3 Soo Jeong Youn ^2,3,4 Patricia Arean ⁵ Andrew Bertagnolli ⁶ Jenna Carl ⁷ Tarolyn Carlton ⁸ Neha Chaudhary ⁹ David Cooper ¹⁰ Shelly DeVito ⁹ Stephanie Eaneff ¹¹ Megan Flom ¹¹ Valerie L Forman-Hoffman ¹¹ Leanna Fortunato ¹² Karen Franchino ¹³ Andrea Kass Graham ¹ Heidi Greenberger ¹⁴ Jessica Hauflaire ¹⁵ Benjamin Kaveladze ¹⁶ Rachel Kornfield ¹ Kaylee P Kruzan ¹ Eric Kuhn ¹⁷ Carolyn Maciver ¹⁸ Frederick Muench ¹⁹ Regina Misch ²⁰ Adrian Ortega ¹ Lisa Palko ² Derek Richards ²¹ Louisa Salhi ²⁰ Jonathan Schremp ²² Eva Szigethy ²³ Nathan Tatro ²⁴ Bethany A Teachman ^2,25 Trina Histon ¹¹

• ¹ Center for Behavioral Intervention Technologies (CBITs), Feinberg School of Medicine, Northwestern University, Chicago, United States
• ² Society for Digital Mental Health, Irvine, CA, United States
• ³ Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, United States
• ⁴ Reliant Medical Group, Worcester, Massachusetts, United States
• ⁵ National Institute of Mental Health (NIH), Bethesda, Maryland, United States
• ⁶ One Medical, San Francisco, United States
• ⁷ Big Health, San Francisco, United States
• ⁸ Otsuka Parmaceutical Development and Commercialization, Princeton, NJ, United States
• ⁹ Modern Health, San Francisco, California, United States
• ¹⁰ TeleDoc, Purchase NY, United States
• ¹¹ Woebot Health, San Francisco, CA, United States
• ¹² American Psychological Association, Washington D.C., District of Columbia, United States
• ¹³ Kaiser Permanente, Oakland, California, United States
• ¹⁴ AbleTo Inc., New York, NY, United States
• ¹⁵ Digital Therapeutics Alliance, Arlington, VA, United States
• ¹⁶ Center for Integrated Behavioral Health, Bethlehem, Pennsylvania, United States
• ¹⁷ National Center for PTSD, VA Palo Alto Healthcare System, Palo Alto, California, United States
• ¹⁸ Adaptive Health, Inc., Chicago, IL, United States
• ¹⁹ Feinstein Institute for Medical Research, New York, New York, United States
• ²⁰ Kooth Digital Health Services, Chicago, IL, United States
• ²¹ Silver Cloud by Amwell, Dublin, Ireland
• ²² Banner Health, Phoenix, Arizona, United States
• ²³ Akron Children's Hospital, Akron, Ohio, United States
• ²⁴ Mental Health America, Alexandria, VA, United States
• ²⁵ University of Virginia, Charlottesville, Virginia, United States

Introduction: Digital mental health treatments (DMHTs) have begun to be implemented in some healthcare systems across the United States. These implementations are conducted as business arrangements. Thus, information on successful or unsuccessful implementations is not published or disseminated. This slows progress, as experiences and learnings are siloed within each organization, hindering or preventing learning across implementations and slowing the progress. To address this, the Society for Digital Mental Health established a DMHT Implementation Workgroup, with the goal of developing a DMHT Playbook that describes current best practices in DMHT implementation in American healthcare settings. Methods: The workgroup was comprised of representatives from 7 healthcare systems and 10 DMHT companies that have conducted implementations, along with other stakeholders and technical experts. The workgroup met virtually to discuss implementation of effective DMHT implementation processes and inform the development of an interview guide, which was then administered to another 20 key opinion leaders with DMHT implementation experience. Concepts and thematic constructs were extracted by experts in qualitative data analysis. These findings were discussed and refined by the Workgroup based on the Workgroup's experience. Results: The resulting playbook includes detailed methods, processes and procedures, representing practices that have been successful for implementing DMHTs in healthcare settings. Discussion: The workgroup recognizes that DMHT implementation is a rapidly evolving field. The successful practices for DMHT implementation described in this playbook may be useful for improving the efficiency of future DMHT implementations in American healthcare systems. However, the authors caution that as the field rapidly evolves, successful implementation practices will likely evolve as well.