Peng Mei ¹ Fuquan Zhang ^2*

• ¹ Party School of the Central Committee of the Communist Party of China, Beijing, China
• ² Minjiang University, Fuzhou, Fujian Province, China

This study aims to leverage the advanced capabilities of quantum computing to construct an efficient framework for processing large-scale health data, uncover potential higher-order correlations in medicine, and enhance the accuracy of smart healthcare diagnosis and treatment. A data processing framework is developed using quantum annealing algorithms and quantum circuits. We call it the quantum medical data simulation computational model(Q-MDSC). A unique encoding method based on quantum bits is employed for health data features, such as encoding symptom information from electronic health records into different quantum bits and representing different alleles of genetic data through superposition states of quantum bits. The properties of quantum entanglement are utilized to relate different data types, and quantum parallelism is harnessed to process multiple data combinations simultaneously. Additionally, this quantum computing framework is compared with traditional data mining methods using the same datasets, which include the Cochrane Systematic Review Database (https://www.cochranelibrary.com),theBioASQDataset (https://participants-area.bioasq.org), the PubMed Central Dataset (https://www.ncbi.nlm.nih.gov/pmc), and the Cancer Genome Atlas (TCGA) (https://portal.gdc.cancer.gov). The datasets are divided into training and testing sets in a 7:3 ratio during the experiments. Tests are conducted on association mining tasks of varying data scales and complexities, ranging from simple symptom-disease associations to complex gene-symptom-disease higher-order associations. The results indicate that, when processing large-scale data, the quantum computing framework improves overall computational speed by approximately 45% compared to traditional algorithms. Regarding uncovering higher-order correlations, the quantum computing framework enhances accuracy by about 30% relative to traditional algorithms. For early disease prediction, the accuracy achieved with the new framework is approximately 25% higher than that of conventional methods. Furthermore, for personalized treatment plan matching, the matching accuracy of the quantum computing framework surpasses traditional approaches by about 35%. These findings demonstrate the significant potential of the quantum computing-based smart healthcare framework for processing large-scale health data in the context of higher-order correlation mining, paving new pathways for the development of smart healthcare. This study utilizes multiple public datasets to achieve breakthroughs in computational speed, higher-order correlation mining, early disease prediction, and personalized treatment plan matching, thus opening new avenues for advancing smart healthcare.