AUTHOR=Zhai Song , Liaw Andy , Shen Judong , Xu Yuting , Svetnik Vladimir , FitzGerald James J. , Antoniades Chrystalina A. , Holder Dan , Dockendorf Marissa F. , Ren Jie , Baumgartner Richard TITLE=A novel machine learning based framework for developing composite digital biomarkers of disease progression JOURNAL=Frontiers in Digital Health VOLUME=6 YEAR=2025 URL=https://www.frontiersin.org/journals/digital-health/articles/10.3389/fdgth.2024.1500811 DOI=10.3389/fdgth.2024.1500811 ISSN=2673-253X