Mihail Tanev ^1* Matthias Klüglich ² Bert Santy ² Kristian Hristov ¹ Tsveta Mincheva ¹

• ¹ FindMeCure Ltd., London, United Kingdom
• ² Boehringer Ingelheim, Ingelheim, Germany

Clinical research increasingly recognizes the role and value of patient-centric data incorporation in trial design, aiming for more relevant, feasible, and engaging studies for participating patients. Despite recognition, research on analytical models regarding qualitative patient data analysis has been insufficient. Aim: This pilot study aims to explore and demonstrate the analytical framework of the "Patient Feasibility" concept -a novel approach for integrating patient-centric data into clinical trial design using psychometric Latent Class Analysis (LCA) and Interval Response Theory (IRT) models. Methods: A qualitative survey was designed to capture the diverse experiences and attitudes of patients in an oncological indication. Result data was subjected to content analysis and categorization as a preparatory phase of the study. The analytical phase further employed LCA and Hybrid IRT models to discern distinct patient subgroups and characteristics related to Patient Feasibility. Results: LCA identified three latent classes each with distinct characteristics pertaining to a latent trait defined as Patient Feasibility. Covariate analyses further highlighted subgroup behaviors. Additionally, IRT analyses using 2 Parameter Logistic Model (2PL), Generalized Partial Credit Model (GPCM), and Nominal Response Model (NRM) highlighted further distinct characteristics of the studied group. The results provided insights into perceived treatment challenges, logistic challenges, and limiting factors regarding both standard of care therapy and clinical trial attitudes.