AUTHOR=Armstrong Kai , Zhang Lei , Wen Yan , Willmott Alexander P. , Lee Paul , Ye Xujiong 

TITLE=A marker-less human motion analysis system for motion-based biomarker identification and quantification in knee disorders

JOURNAL=Frontiers in Digital Health

VOLUME=6

YEAR=2024

URL=https://www.frontiersin.org/journals/digital-health/articles/10.3389/fdgth.2024.1324511

DOI=10.3389/fdgth.2024.1324511

ISSN=2673-253X

ABSTRACT=<p>In recent years the healthcare industry has had increased difficulty seeing all low-risk patients, including but not limited to suspected osteoarthritis (OA) patients. To help address the increased waiting lists and shortages of staff, we propose a novel method of automated biomarker identification and quantification for the monitoring of treatment or disease progression through the analysis of clinical motion data captured from a standard RGB video camera. The proposed method allows for the measurement of biomechanics information and analysis of their clinical significance, in both a cheap and sensitive alternative to the traditional motion capture techniques. These methods and results validate the capabilities of standard RGB cameras in clinical environments to capture clinically relevant motion data. Our method focuses on generating 3D human shape and pose from 2D video data via adversarial training in a deep neural network with a self-attention mechanism to encode both spatial and temporal information. Biomarker identification using Principal Component Analysis (PCA) allows the production of representative features from motion data and uses these to generate a clinical report automatically. These new biomarkers can then be used to assess the success of treatment and track the progress of rehabilitation or to monitor the progression of the disease. These methods have been validated with a small clinical study, by administering a local anaesthetic to a small population with knee pain, this allows these new representative biomarkers to be validated as statistically significant (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM1"><mml:mi>p</mml:mi></mml:math></inline-formula>-value <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM2"><mml:mo>&lt;</mml:mo><mml:mn>0.05</mml:mn></mml:math></inline-formula>). These significant biomarkers include the cumulative acceleration of elbow flexion/extension in a sit-to-stand, as well as the smoothness of the knee and elbow flexion/extension in both a squat and sit-to-stand.</p>