AUTHOR=Villa Nova Mônica , Lin Tzu Ping , Shanehsazzadeh Saeed , Jain Kinjal , Ng Samuel Cheng Yong , Wacker Richard , Chichakly Karim , Wacker Matthias G. TITLE=Nanomedicine Ex Machina: Between Model-Informed Development and Artificial Intelligence JOURNAL=Frontiers in Digital Health VOLUME=4 YEAR=2022 URL=https://www.frontiersin.org/journals/digital-health/articles/10.3389/fdgth.2022.799341 DOI=10.3389/fdgth.2022.799341 ISSN=2673-253X ABSTRACT=

Today, a growing number of computational aids and simulations are shaping model-informed drug development. Artificial intelligence, a family of self-learning algorithms, is only the latest emerging trend applied by academic researchers and the pharmaceutical industry. Nanomedicine successfully conquered several niche markets and offers a wide variety of innovative drug delivery strategies. Still, only a small number of patients benefit from these advanced treatments, and the number of data sources is very limited. As a consequence, “big data” approaches are not always feasible and smart combinations of human and artificial intelligence define the research landscape. These methodologies will potentially transform the future of nanomedicine and define new challenges and limitations of machine learning in their development. In our review, we present an overview of modeling and artificial intelligence applications in the development and manufacture of nanomedicines. Also, we elucidate the role of each method as a facilitator of breakthroughs and highlight important limitations.