AUTHOR=Ilan Yaron TITLE=Second-Generation Digital Health Platforms: Placing the Patient at the Center and Focusing on Clinical Outcomes JOURNAL=Frontiers in Digital Health VOLUME=2 YEAR=2020 URL=https://www.frontiersin.org/journals/digital-health/articles/10.3389/fdgth.2020.569178 DOI=10.3389/fdgth.2020.569178 ISSN=2673-253X ABSTRACT=

Artificial intelligence (AI) digital health systems have drawn much attention over the last decade. However, their implementation into medical practice occurs at a much slower pace than expected. This paper reviews some of the achievements of first-generation AI systems, and the barriers facing their implementation into medical practice. The development of second-generation AI systems is discussed with a focus on overcoming some of these obstacles. Second-generation systems are aimed at focusing on a single subject and on improving patients' clinical outcomes. A personalized closed-loop system designed to improve end-organ function and the patient's response to chronic therapies is presented. The system introduces a platform which implements a personalized therapeutic regimen and introduces quantifiable individualized-variability patterns into its algorithm. The platform is designed to achieve a clinically meaningful endpoint by ensuring that chronic therapies will have sustainable effect while overcoming compensatory mechanisms associated with disease progression and drug resistance. Second-generation systems are expected to assist patients and providers in adopting and implementing of these systems into everyday care.