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SYSTEMATIC REVIEW article

Front. Dent. Med
Sec. Endodontics
Volume 5 - 2024 | doi: 10.3389/fdmed.2024.1498353
This article is part of the Research Topic Integrated Inflammology in Endodontics View all 3 articles

Antibacterial activity of Biodentine against Enterococcus faecalis: A Systematic Review

Provisionally accepted
Hasan Subhi Hasan Subhi 1*Nashwah Subhi Nashwah Subhi 2Salah Alhaidary Salah Alhaidary 3Mahmood S Azeez Mahmood S Azeez 4Abedelmalek Kalefh Tabnjh Abedelmalek Kalefh Tabnjh 5,6*
  • 1 School of Dental Sciences, Universiti Sains Malaysia Health Campus, Kota Bharu, Kelantan, Malaysia
  • 2 Department of Prosthetic Dentistry, College of Dentistry, University of Mosul, Mosul,, Iraq
  • 3 Department of Orthodontics, Faculty of Dentistry, Ibn Al-Nafis University, Sana’a, Yemen
  • 4 Azhar Private Hospital, Muscat, Oman
  • 5 University of Gothenburg, Gothenburg, Sweden
  • 6 Jordan University of Science and Technology, Irbid, Irbid, Jordan

The final, formatted version of the article will be published soon.

    Biodentine is a well-known endodontic material that is applied in various endodontic therapies.Enterococcus faecalis (E. faecalis) is associated with endodontic failure and persistent periapical infection. The purpose of this systematic review was to summarize the available evidence regarding the antibacterial activity of Biodentine against E. faecalis and to compare it to other commercial endodontic materials. An electronic search of literature was conducted in PubMed, Scopus, Web of Science, and Google Scholar in addition to a manual search in specialized journals up to May 2024. The eligibility criteria, data extraction, and evaluation of risk of bias were assessed by two independent authors. The risk of bias was evaluated in accordance with Modified CONSORT checklist items for pre-clinical in vitro studies on dental materials. Out of 343 studies, thirty-seven fulfilled the inclusion criteria and were included in this review. Thirty studies reported a good antibacterial efficacy of Biodentine against E. faecalis. Biodentine was superior to or, at least, as efficacious as MTA, MTA Angelus, GIC, RMGIC, DiaRoot BioAggregate, NeoPutty, iRoot FS, MTA Repair HP, MTA Biorep, Well-Root PT, Activa, NeoMTA 2, Calcimol LC, TotalFill, and IRM. The findings were supported by studies with medium to high risk of bias (low quality). Considering the limitations of this systematic review, there is accumulating evidence on the antibacterial activity of Biodentine against E. faecalis in context of endodontics. However, randomized clinical trials with welldesigned and robust methodologies are required in order to provide information about its clinical behaviour.

    Keywords: Antibacterial, Biodentine, Enterococcus faecalis, Endodontic treatment, Endodontic failure, Systematic review

    Received: 18 Sep 2024; Accepted: 30 Dec 2024.

    Copyright: © 2024 Subhi, Subhi, Alhaidary, Azeez and Tabnjh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Hasan Subhi, School of Dental Sciences, Universiti Sains Malaysia Health Campus, Kota Bharu, Kelantan, Malaysia
    Abedelmalek Kalefh Tabnjh, University of Gothenburg, Gothenburg, Sweden

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.