Xin Meng ¹ Juan Hui Qu ^2* Ying Xue Zhang ^1* Min Min Sun ^1,2* Hai Hong Ji ^1,2* Yun Ai Hu ^2*

• ¹ School of Stomatology, Shandong Second Medical University, WeiFang, China
• ² Department of Stomatology, The Affiliated Hospital of Shandong Second Medical University, WeiFang, China

Today, more than 200 million people worldwide suffer from osteoporosis, and the number of people with osteoporosis remains high with the accelerated aging process; on the other hand, nearly 19% of the global adult population suffers from severe periodontitis, with more than 1 billion cases worldwide. Osteoporosis is a common systemic metabolic bone disease characterized by decreased bone mass, increased bone fragility and destroyed bone microstructure. Closely linked to systemic health, periodontitis is a chronic infectious disease that can lead to the destruction of periodontal tissues. Both diseases are age-related, common in middle-aged and older people, and characterized by destruction of bone resorption and loss of bone mass. Some studies have shown that osteoporosis is associated with periodontitis, that it increases with severity, and that there's a positive correlation between bone mineral density and periodontitis. They also share some common pathogenic mechanisms, such as intracellular reactive oxygen species, estrogen deficiency, immune inflammation and glycosylation. A growing body of evidence has identified oxidative stress as an important factor contributing to the progression of osteoporosis and periodontitis. In this paper, we will review the manifestations and roles of oxidative stress in the development of osteoporosis and periodontitis, and explore the correlation between the two, with a view to providing new approaches and ideas for the prevention and treatment of osteoporosis and periodontitis.