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MINI REVIEW article

Front. Dent. Med
Sec. Endodontics
Volume 5 - 2024 | doi: 10.3389/fdmed.2024.1426887
This article is part of the Research Topic Integrated Inflammology in Endodontics View all articles

Characteristics of inflammatory mediators in dental pulp inflammation and the potential for their control

Provisionally accepted
Nobuyuki Kawashima Nobuyuki Kawashima *Takashi Okiji Takashi Okiji
  • Tokyo Medical and Dental University, Tokyo, Japan

The final, formatted version of the article will be published soon.

    Dental pulp is a mesenchymal connective tissue located inside the rigid encasement of the dentin.When bacteria or bacterial products invade the dental pulp, inflammation known as pulpitis is induced in this tissue. Various mediators produced during the course of pulpitis profoundly modify the pathophysiology of the inflammation. Typical mediators include cytokines, chemokines, nitric oxide, reactive oxygen species, matrix metalloproteinases, proteases, neutrophil extracellular traps, neuropeptides, and eicosanoids. Controlling these mediators may potentially lead to the healing of pulpitis and the preservation of pulp tissue. This review discusses these mediators and further explores the possibility of controlling them.

    Keywords: Inflammation, mediators, Dental Pulp, inflammatory cells, inflammatory control

    Received: 02 May 2024; Accepted: 24 Jul 2024.

    Copyright: © 2024 Kawashima and Okiji. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Nobuyuki Kawashima, Tokyo Medical and Dental University, Tokyo, Japan

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.