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SYSTEMATIC REVIEW article

Front. Dent. Med
Sec. Periodontics
Volume 5 - 2024 | doi: 10.3389/fdmed.2024.1418039

A systematic review of a novel alloplast carbonate apatite granules

Provisionally accepted
Martha Nunn Martha Nunn 1*Courtney Rudick Courtney Rudick 1Masahiko Nikaido Masahiko Nikaido 2,3Takanari Miyamoto Takanari Miyamoto 1,4
  • 1 Independent researcher, Omaha, NE, United States
  • 2 Tokyo Dental College, Chiyoda, Tokyo, Japan
  • 3 Independent researcher, Tokyo, Japan
  • 4 School of Dentistry, Creighton University, Omaha, Nebraska, United States

The final, formatted version of the article will be published soon.

    The objectives of this study are to provide a systematic review of a novel alloplastic hard-tissue grafting material, carbonate apatite granules (CO3Ap-granules), to provide a clinical case presentation of carbonate apatite granulesCO3Ap-granules in periodontal surgery. The following three electronic databases were searched independently by two of the authors (MN) and (CR): National Library of Medicine (MEDLINE [PubMed] and ClinicalTrials.gov), EMBASE (OVID) and the Cochrane Central Register of Controlled Trials (CENTRAL). After searching electronic databases, select journals in periodontics and implantology were also manually searched. Of the 43 studies identified from the systematic review, the following classifications were determined: (1) in vitro studies -5 studies, (2) animal studies -28 studies, (3) clinical studies -7 studies, (4) reviews -3 studies. Results from selected animal studies and all human studies were summarized. These results demonstrate that the novel alloplast carbonate apatite granulesCO3Ap-granules has the potential ability to stimulate new bone formation while carbonate apatite granulesCO3Ap-granules simultaneously resorb over time. Replacement of carbonate apatite granulesCO3Ap-granules with new bone formation has been shown to be comparable to autogenous bone grafting with one study showing superior results to a bovine-derived xenograft.

    Keywords: Alloplast, hard-tissue graft, carbonate apatite granules, Cytrans Granules, Artificial bone

    Received: 15 Apr 2024; Accepted: 18 Jul 2024.

    Copyright: © 2024 Nunn, Rudick, Nikaido and Miyamoto. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Martha Nunn, Independent researcher, Omaha, NE, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.