AUTHOR=Lorencetti-Silva Francine , Sales Larissa Sthefani , Lamarque Giuliana de Campos Chaves , Caixeta Giovana Amorim , Arnez Maya Fernanda Manfrin , Faccioli Lúcia Helena , Paula-Silva Francisco Wanderley Garcia TITLE=Effects of inflammation in dental pulp cell differentiation and reparative response JOURNAL=Frontiers in Dental Medicine VOLUME=3 YEAR=2022 URL=https://www.frontiersin.org/journals/dental-medicine/articles/10.3389/fdmed.2022.942714 DOI=10.3389/fdmed.2022.942714 ISSN=2673-4915 ABSTRACT=

The responsiveness of the dentin–pulp complex is possible due to the stimulation of dental pulp cells, which begin to synthesize and secrete dentin matrix. The inflammatory process generated by harmful stimuli should be understood as a natural event of the immune response, resulting in the recruitment of hematopoietic cells, which cross the endothelial barrier and reach the site affected by the injury in order to eliminate the damage and provide an appropriate environment for the restoration of homeostasis. The repair process occurs in the presence of adequate blood supply, absence of infection, and with the participation of pro-inflammatory cytokines, growth factors, extracellular matrix components, and other biologically active molecules. Prostaglandins and leukotrienes are bioactive molecules derived from the metabolism of arachidonic acid, as a result of a variable range of cellular stimuli. The aim of this review is to describe the process of formation and biomineralization of the dentin–pulp complex and how pro-inflammatory events can modify this response, with emphasis on the lipid mediators prostaglandins and leukotrienes derived from arachidonic acid metabolism.